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Abstract

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopamineproducing neurons, leading to motor and non-motor symptoms. Oxidative stress and neuroinflammation play pivotal roles in the disease’s pathogenesis. Plant-based polyphenols, known for their antioxidant and anti-inflammatory properties, offer a promising approach to mitigating these pathological processes. This review explores the potential of polyphenols, such as curcumin, resveratrol, and epigallocatechin gallate (EGCG), in combating Parkinson’s disease. These compounds address oxidative stress by scavenging free radicals and enhancing endogenous antioxidant defenses, while also reducing neuroinflammation by inhibiting pro-inflammatory cytokines and microglial activation. Preclinical and clinical evidence supports their efficacy in protecting dopaminergic neurons and improving motor and cognitive functions. Despite challenges related to bioavailability and the need for further clinical validation, plantbased polyphenols represent a novel and promising strategy for managing Parkinson’s disease and improving patient outcomes.