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Abstract

Gastric or oesophageal neuroendocrine carcinoma is very rare disease. Both biological and therapeutic features are different from the common type including pathological findings either squamous cell carcinoma or adenocarcinoma. We have experienced five cases of gastric and oesophageal neuroendocrine carcinoma. Case 1: A 55-year-old woman visited our hospital complaining of upper abdominal pain. A type 2 tumor in the middle of the oesophagus was detected by upper endoscopy, and multiple liver metastases were detected by computed tomography (CT). She underwent chemotherapy but she died within 15 months of being diagnosed with her disease. Case 2: A 73-year-old man visited our hospital complaining of light inguinal pain. A type 2 tumor in the lower of the oesophagus was detected by upper-endoscopy and bone metastatic findings were seen in the left ilium. He underwent chemotherapy but he then developed progressive disease with increasing tumor markers. Case 3: A 56-year-old man visited our hospital complaining of digestive obstruction. A type 2 tumor in the lower-oesophagus was detected by upper-endoscopy. He received chemotherapy after CT revealed an unresectable state due to para-aortic lymph node metastasis. He was noted to have progressive disease based on CT. He is being maintained on chemotherapy. Case 4: A 74-year-old man visited our hospital complaining of reflux esophagitis. A type 2 tumor in body of his stomach was detected by upper-endoscopy and liver metastatic findings were detected on PET-CT, so we diagnosed neuroendocrine gastric carcinoma. He underwent chemotherapy. He died within 12 months of being diagnosed with his disease. Case 5: A 73-year-old man visited a different hospital with complaints of abdominal pain. A type 2 tumor in the antrum of the stomach was detected by upper endoscopy. He underwent surgery but he had a diagnosis of a recurrence in the pancreas.

Keywords: Small cell carcinoma; Neuroendocrine carcinoma; Gastric cancer; Oesophageal cancer