Research Article
FORMULATION AND EVALUATION OF IMMEDIATE AND SUSTAINED RELEASE BILAYERED TABLET WITH GLIBENCLAMIDE AND METFORMIN HYDROCHLORIDE
Abstract
The aim of the present research work is to develop bilayer tablet dosage form containing combination of immediate and sustained release layer prepared using Glibenclamide and Metformin Hydrochloride respectively for the treatment of Type-11 diabetes mellitus. Immediate release of glibenclamide granules was prepared with different superdisintegrant. Metformin hydrochloride sustained release granules were prepared by non-aqueous wet granulation technique. Both pre-compression and post compression parameters were analyzed for all the tablets. Bilayer tablets was formulated using croscarmellose sodium for immediate release of Glibenclamide showed 99.94% of release in 30 minutes and using hydrophilic HPMC K100 and hydrophobic Ethyl cellulose in the ratio of 1:1 released 99.90% of Metformin hydrochloride for the period of 13 hours. From this research work it is evident that the formulated bilayer tablet has ability to release the Glibenclamide immediately and Metformin hydrochloride for longer period of time, which can be used for treatment of type11 diabetes mellitus compared to Marketed formulation.
