From Heterogeneity to Hope: Uniting Efforts in Atherosclerosis Research and Therapeutic Development
Received Date: Apr 26, 2023 / Accepted Date: May 24, 2023 / Published Date: May 25, 2023
Abstract
The utilization of single cell technologies, lineage tracing mouse models, and advanced imaging techniques has significantly enhanced our understanding of the cellular landscape of atherosclerosis. These advancements have provided a clearer resolution of the diverse cellular states involved in the progression of atherosclerosis. However, this increased knowledge has also introduced greater complexity to current and future research, requiring a reevaluation of our approach to drug development. This review explores the impact of recent advancements in single cell technologies, which have allowed us to map the intricate cellular networks within atherosclerotic plaques. Additionally, we address the existing technological limitations that hinder our ability to identify the key cellular drivers of the disease and identify specific cell states, subsets, or surface antigens as potential drug targets for atherosclerosis.
Citation: David J (2023) From Heterogeneity to Hope: Uniting Efforts inAtherosclerosis Research and Therapeutic Development. Atheroscler OpenAccess 8: 204. Doi: 10.4172/asoa.1000204
Copyright: © 2023 David J. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.
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