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Abstract

The multifaceted nature of functionalized magnetic nanoparticles (fMNPs) makes them suitable for cancer therapy. These Nano composites can also provide a multimodal platform for targeted cancer therapy due to their unique magnetic induction properties. When induced by an alternating magnetic field (AMF), fMNPs can convert magneto static energy into heat for magnetic hyperthermia (MHT) and controlled drug release. In addition, fMNPs are also of interest for photo thermal therapy (PTT) with their ability to convert near-infrared (NIR) light energy into thermal energy. In addition to MHT and PTT, fMNPs are also used in combination therapies against cancer, such as chemical MHT, chemical PTT, and photodynamic therapy using chemical PTT, due to their versatile properties. Therefore, in this review, we present fMNP-based multifunctional Nano composites for cancer treatment with AMF or NIR light. We first describe various fMNPs induced by AMF in cancer MHT and chemotherapy MHT. Next, we describe fMNP by NIR laser irradiation for cancer PTT and chemotherapy PTT. Finally, we describe fMNPs used for dual AMF + NIR laser-induced magnetooptical hyperthermia (MPHT).

Keywords: Magnetic nanoparticles; Magnetic hyperthermia; Photo thermal therapy; Magnetic targeting; Alternating magnetic field; Near Infrared