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Abstract

Global immunization efforts have made significant strides in reducing the burden of vaccine-preventable diseases, yet several challenges persist in achieving universal pediatric vaccination. These challenges include vaccine accessibility, hesitancy, logistical barriers, and the emerging need for personalized immunization strategies. This paper explores these ongoing challenges and highlights innovative solutions aimed at overcoming them. Key solutions include the development of thermostable vaccines, which do not require a cold chain, needle-free delivery systems, and mRNA vaccine platforms that offer rapid response capabilities for emerging diseases. Additionally, global initiatives such as GAVI and the World Health Organization’s Expanded Program on Immunization (EPI) are playing critical roles in expanding access to vaccines in underserved regions. By examining these challenges and solutions, this paper emphasizes the importance of global collaboration, policy frameworks, and technological innovations in achieving the goal of universal pediatric immunization, ensuring every child has the opportunity to live a healthy life free from preventable diseases.