High Serum Level of Secreted Frizzled-Related Protein 5 (sfrp5) is Associated with Future Cardiovascular Events

Hongwei Ji; Hailing Li; Jianhui Zhuang; Yang Su; Jing Wen; Jingying Zhang; Dongdong Zhao; Yi Zhang; YaWei Xu

High Serum Level of Secreted Frizzled-Related Protein 5 (sfrp5) is Associated with Future Cardiovascular Events

Hongwei Ji, Hailing Li, Jianhui Zhuang, Yang Su, Jing Wen, Jingying Zhang, Dongdong Zhao, Yi Zhang^* and YaWei Xu^*: Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

^*Corresponding Author (s) : Yi Zhang MD, PhD, Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China, Tel: +086-21-66307274, Fax: 086-21-66306381, Email: yizshcn@gmail.com

YaWei Xu MD, PhD, FACC, FESC, Department of Cardiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China, Tel: +086-21-66307274, Fax: 086-21-66306381, Email: xuyawei@tongji.edu.cn

Received Date: Feb 13, 2017 / Accepted Date: Mar 17, 2017 / Published Date: Mar 25, 2017

Abstract

Objectives: Novel biomarkers to predict future risk of coronary artery disease, especially in the early stage, are warranted. The goal of this study was to determine whether SFRP5, a novel anti-inflammatory adipokine, is associated with future cardiovascular events.
Methods: This is a 4-year follow-up study that included 81 subjects with CAG (+) and 87 subjects with CAG (-). SFRP5 levels was analyzed by ELISA. 2-year and 4-year follow-up were conducted for the occurrence of major adverse cardiac events (MACE), including unstable angina pectoris, ischemic stroke, nonfatal myocardial infarction, revascularization, and cardiovascular death.
Results: In multivariate Cox regression analysis, high SFRP5 significantly predicted patients’ MACE with an HR of 2.174 (95% CI 1.169, 4.041; p=0.014) at 2-year follow-up, and with an HR of 1.974 (95% CI 1.138, 3.426; p=0.016) at 4-year follow-up respectively. The incidence of MACE was significantly increased in the high SFRP5 group for CAG(-) patients ((HR (95%CI) 3.326(1.275, 8.680), p=0.014 for 2-year; HR (95%CI) 2.590(1.122, 5.978), p=0.026) for 4-year), as well as for patients over 65 years (HR(95%CI) 4.931(1.989, 12.222), p<0.001 for 2-year; HR(95%CI) 3.194(1.541, 6.621), p=0.002 for 4-year, respectively).
Conclusion: A high serum concentration of SFRP5 is associated with the occurrence of future CV events,especially in the elderly.

Keywords: SFRP5; Coronaryarterydisease; Cardiovascularevent; Angiography; Hypertension; Inflammation

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Citation: Ji H, Li H, Zhuang J, Su Y, Wen J, et al. (2017) High Serum Level of Secreted Frizzled-Related Protein 5 (sfrp5) is Associated with Future Cardiovascular Events. Cardiovasc Ther 2: 115.

Copyright: © 2017 Ji H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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