Hippocampal Sclerosis and Epilepsy in Elderly Population

Tuomas  Rauramaa; Alina  Solomon; Maria  Pikkarainen; Reetta  Kälviäinen; Irina  Alafuzoff

doi:10.4172/2161-0460.1000384

ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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Research Article
J Alzheimers Dis Parkinsonism 2017, Vol 7(5): 384
DOI: 10.4172/2161-0460.1000384

Hippocampal Sclerosis and Epilepsy in Elderly Population

Tuomas Rauramaa^1,^2,³^*, Alina Solomon^4,⁵, Maria Pikkarainen^2,³, Reetta Kälviäinen^6,⁷ and Irina Alafuzoff^8,⁹: ¹Department of Pathology, Kuopio University Hospital, , Finland; ²Institute of Clinical Medicine, Unit of Pathology, University of Eastern Finland, Finland; ³Institute of Clinical Medicine, Unit of Neurology, University of Eastern Finland, Finland; ⁴Institute of Clinical Medicine/Neurology, University of Eastern Finland, Finland; ⁵Center for Alzheimer Research, Karolinska Institutet, , Huddinge, Sweden; ⁶Department of Neurology, Kuopio University Hospital, , Finland; ⁷Department of Neurology, School of Medicine, University of Eastern Finland, Finland; ⁸Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden; ⁹Department of Pathology and Cytology, Uppsala University Hospital, , Sweden

^*Corresponding Author : Tuomas Rauramaa, Department of Clinical Pathology, Kuopio University Hospital, P.O. Box 1777 FIN-70211, Kuopio, Finland, Tel: +358445346179, Email: tuomas.rauramaa@kuh.fi

Received Date: Nov 15, 2017 / Accepted Date: Oct 06, 2017 / Published Date: Oct 13, 2017

Abstract

Objective: In temporal lobe epilepsy, hippocampal sclerosis (HS) and Alzheimer’s disease (AD) pathological alterations in the hippocampus are frequently observed. Methods: We assessed the clinicopathological characteristics of 30 aged subjects with HS originating from a large unselected autopsy cohort including 1,388 individuals. Results: Overall, in 22 subjects AD related pathology and in 17 subjects TDP43 pathology, from mild, moderate to severe was seen. Five subjects out of 30 (17%) with HS had epilepsy. Conclusion: A higher percentage compared to the reported prevalence of epilepsy in 0.6 percent of the adult population was observed, but more post mortem studies are urgently needed to investigate the pathological substrate for epilepsy in AD.

Keywords: Hippocampus; Postmortem; Hippocampal sclerosis; Epilepsy; Alzheimer

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Citation: Rauramaa T, Solomon A, Pikkarainen M, Kälviäinen R, Alafuzoff I, et al. (2017) Hippocampal Sclerosis and Epilepsy in Elderly Population. J Alzheimers Dis Parkinsonism 7: 384. Doi: 10.4172/2161-0460.1000384

Copyright: © 2017 Rauramaa T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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