Human Brain Microvascular Endothelial Cells Are Infected By the TickBorne Encephalitis Virus, But the Blood-Brain Barrier Is Not Compromised
Received Date: Mar 01, 2024 / Published Date: Mar 29, 2024
Abstract
Tick-borne encephalitis virus (TBEV) is a significant cause of viral encephalitis in humans transmitted by ticks. The central nervous system (CNS) invasion by TBEV poses a serious threat to human health. Understanding the mechanisms underlying the interaction between TBEV and the blood-brain barrier (BBB) is crucial for developing effective therapeutic strategies. Here, we investigated the infection of human brain microvascular endothelial cells (HBMECs) by TBEV and assessed the integrity of the BBB upon viral exposure. Our results demonstrate that TBEV can infect HBMECs without compromising the BBB integrity, suggesting potential avenues for therapeutic intervention in TBEV-induced encephalitis.
Citation: Stoma B (2024) Human Brain Microvascular Endothelial Cells AreInfected By the Tick-Borne Encephalitis Virus, But the Blood-Brain Barrier Is NotCompromised. J Neuroinfect Dis 15: 497. Doi: 10.4172/2314-7326.1000497
Copyright: © 2024 Stoma B. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.
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