Review Article
Identification and Prevention of Serotonin Syndrome
Mohammad Masud Iqbal1*, Saabry Yusof Osmany2, Mohamamd Tamzid Iqbal3
1Central New York Psychiatric Center, Marcy, NY, USA
2Paragon Medical Center, Radlink PET and Cardiac Imaging, Singapore
3University of Buffalo, Buffalo, NY, USA
Abstract
Serotonin Syndrome (SS) is a rare, but lethal, adverse drug reaction caused by excessive serotonin activity in the nervous system. Serotonin syndrome is more accurately described as serotonin toxicity and can be triggered by serotonergic agents either alone or in combination with monoamine oxidase inhibitors (MAOIs). It may occur after one standard therapeutic dose of a single agent, unintentional interactions between various medications, drug overdose, as well as recreational drug use. Symptoms present as alteration of mental status, abnormalities of neuromuscular tone, and autonomic hyperactivity. Although effects are usually mild and resolve with prompt recognition and supportive care, there exists a strong need for integration of these preventative measures in current clinical practice.
