Impact of Posture on Pharmacokinetics
*Corresponding Author:Received Date: Dec 01, 2023 / Accepted Date: Dec 30, 2023 / Published Date: Dec 30, 2023
Copyright: © 2024 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The pharmacokinetics of drugs, encompassing absorption, distribution, metabolism, and elimination, is a
dynamic interplay within the intricate landscape of the human body. The physiological changes associated with
alterations in body position can significantly influence drug behavior, with implications for dosing regimens and
therapeutic outcomes. In the realm of drug absorption, posture plays a pivotal role in determining the rate and extent
of gastrointestinal absorption. Changes in blood flow to the gastrointestinal mucosa, coupled with alterations in the
kinetics of gastric emptying, contribute to variations in drug absorption kinetics. For trans dermally administered drugs, the perfusion of the skin is subject to posture-dependent fluctuations, thereby influencing the absorption rate. This abstract sheds light on the often-overlooked factor of posture and its consequential impact on the pharmacokinetic profile of various medications.
