Impacts of Interleukin-17 Neutralization on the Inflammatory Response in a Healing Ligament
Received Date: Mar 15, 2017 / Accepted Date: Mar 30, 2017 / Published Date: Apr 06, 2017
Abstract
In this study, we sought to improve ligament healing by modulating the inflammatory response after acute injury through the neutralization of Interleukin-17 (IL-17), which we hypothesized would decrease inflammatory cell infiltration and cytokine production. Administration of an Interleukin-17 neutralizing antibody (IL-17 NA) immediately following a rat medial collateral ligament (MCL) transection resulted in alterations in inflammatory cell populations and cytokine expression within the healing ligament, but did not reduce inflammation. Specifically, treatment resulted in a decrease in M2 (antiinflammatory) macrophages, an increase in T cells, and an increase in the levels of IL-2, IL-6, and IL-12 in the MCL 7 days post injury. IL-17NA treatment, and subsequent immunomodulation, did not result in improved ligament healing, as measured by collagen composition and wound size.
Keywords: Interleukin-17; Medial collateral ligament; Ligament healing; Immunomodulation
Citation: Clements AEB, Chamberlain CS, Leiferman EM, Murphy WL, Vanderby R (2017) Impacts of Interleukin-17 Neutralization on the Inflammatory Response in a Healing Ligament. J Cytokine Biol 2: 113. Doi: 10.4172/2576-3881.1000113
Copyright: © 2017 Clements AEB et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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