Induced Activation of the Procoagulant Pathways and the Pathogenesis of Ischemia, Venous Thrombosis
Received Date: Jul 29, 2022 / Accepted Date: Aug 22, 2022 / Published Date: Aug 25, 2022
Abstract
A pathway is outlined through which diminished levels of oxygen activate the transcription factor early growth response-1 (Egr-1) leading to de novo transcription/translation of tissue factor in mononuclear phagocytes and smooth muscle cells, which eventuates in vascular fibrin deposition. The procoagulant response is magnified by concomitant suppression of fibrinolysis by hypoxia-mediated upregulation of plasminogen activator inhibitor-1. These data add a new facet to the biology of thrombosis associated with hypoxemia/stasis and imply that interference with mechanisms causing Egr-1 activation in response to oxygen deprivation might prevent vascular fibrin deposition occurring in ischemia without directly interfering with other pro/anticoagulant pathways.
Citation: Yan SF, Mackman N, Kisiel W, Stern D, Pinsky D (2022) Induced Activation of the Procoagulant Pathways and the Pathogenesis of Ischemia, Venous Thrombosis. Atheroscler 黑料网 7: 182.
Copyright: © 2022 Yan SF, et al.. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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