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Abstract

Lymphoid fibroblast development factors are essential for blood vessels and angiogenesis due to their role in endothelial cell proliferation and migration. Fibroblasts, as vascular growth factors, are a hallmark of cancer, and associations between genetic polymorphisms and neoplasia have been extensively studied in the adult population.Regarding the neonatal population, few studies have attempted to establish associations between FIBROBLAST polymorphisms and neonatal pathologies, especially those associated with late complications. Our aim was to review the literature on FIBROBLAST polymorphisms and neonatal morbidity. A systematic search was first conducted in December 2022. The PubMed platform was used to survey MEDLINE and PubMed Central (2000-2022) by applying search strings. A PubMed search returned 62 documents. (Low birth weight or preterm infants, heart disease, lung disease, eye disease, brain disease, gastrointestinal disease). FIBROBLAST polymorphisms appear to be associated with neonatal pathologies. FIBROBLAST and FIBROBLAST polymorphisms have been implicated in retinopathy of prematurity.