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Abstract

Maintaining immune balance is essential for optimal health, and dysregulated immune responses can lead to various diseases, including autoimmune disorders and chronic inflammation. Cytokines play a central role in immune signaling, orchestrating the body’s response to pathogens and threats. While cytokine inhibitors have been explored as therapeutic agents for modulating immune responses, a new frontier has emerged with constitutive cytokine inhibitors. These endogenously expressed molecules offer continuous regulation of cytokine signaling, presenting a novel approach to restoring immune harmony. In this abstract, we delve into the promise and potential of constitutive cytokine inhibitors, exploring their mechanisms of action, therapeutic implications, and future directions. By understanding and harnessing the body’s natural mechanisms of immune regulation, constitutive cytokine inhibitors offer exciting possibilities for precision immunotherapy and improved management of immunerelated diseases.