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Modeling Mechanisms and Applications of Parkinson's Disease Animal Models

Yu Cui^1,2, Yutong Liang¹, Yanshuang Liu^1,3 and Bo Zhang^1*

¹Department of Neuroscience, Heilongjiang University of Chinese Medicine, Harbin, China

²Department of Veterinary Medcine, Hainan University, Haikou, China

³Department of Medical Administration, Lianshui County Chinese Medicine Hospital, Huaian, China

Received Date: Aug 29, 2022 / Published Date: Sep 29, 2022

Citation: Cui Y, Liang Y, Liu Y, Zhang B (2022) Modeling Mechanisms and Applications of Parkinson's Disease Animal Models. J Alzheimers Dis Parkinsonism 12: 550.DOI: 10.4172/2161-0460.1000550

Copyright: © 2022 Cui Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Parkinson's Disease (PD) is a neurodegenerative disorder characterized by the progressive and irreversible loss of Dopaminergic (DA) neurons in the midbrain substantia nigra and the formation of intracytoplasmic inclusion structures or Lewy Bodies (LB’s). However, the etiology and pathogenesis of PD remain unclear. Animal models are essential to study the pathogenesis of PD and identify novel therapeutic targets for its treatment. The first PD model developed was the reserpine model, which was followed by the 6-hydroxydopamine, MPTP, rotenone, and gene models. Several animal models have been used to elucidate different aspects of the molecular mechanisms of DA neuron death and potential therapeutic drugs. The specific modeling mechanisms and applications of each model are therefore different. In this paper, we review the modeling mechanisms and applications of PD animal models in recent years.

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