Conference Proceeding
Molecular Docking to Test for Efficacy of Porphyrin Compounds to Cure Alzheimers Disease
Nadeem Kizilbash1* and Majed Alrowaili21Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Northern Border University, P.O. Box 1321, Arar-91431, Saudi Arabia
2Department of Surgery, Faculty of Medicine, Northern Border University, P.O. Box 1321, Arar-91431, Saudi Arabia
- Corresponding Author:
- Nadeem Kizilbash
Faculty of Applied Medical Sciences
Department of Medical Lab Technology
Northern Border University, Arar-91431, Saudi Arabia
E-mail: fsd707@gmail.com
Received date: August 22, 2015; Accepted date: September 14, 2015; Published date: September 21, 2015
Citation: Kizilbash N, Alrowaili M (2015) Molecular Docking to Test for Efficacy of Porphyrin Compounds to Cure Alzheimer’s Disease. J Biotechnol Biomater 5:199. doi:10.4172/2155-952X.1000199
Copyright: © 2015 Kizilbash N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The cure for Alzheimer's disease involves searching for candidate compounds that can act as inhibitors for Acetylcholinesterase (AChE) enzyme. Regional cerebral blood flow can be increased in patients with Alzheimer’s disease by Acetylcholinesterase inhibitors. In this regard, Tetraphenylporphinesulfonate (TPPS), 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinatoIron(III) nitrosyl Chloride (FeNOTPPS) were investigated as candidate compounds for inhibition of Acteylcholinesterase of Drosophila melanogaster (DmAChE) by use of Molecular Docking. FeNOTPPS was found to form the most stable complex with DmAChE.
