Molecular Mechanism of Diabetic Retinopathy and Its Pharmacotherapy: A Brief Review
Received Date: Feb 01, 2023 / Accepted Date: Feb 27, 2023 / Published Date: Feb 28, 2023
Abstract
Diabetic retinopathy (DR) is associated with vascular dysfunction in retinal vascular system and is the cause of blindness among affected persons. It is one of the life-threatening complications of diabetes mellitus (DM). The STAT proteins, vascular endothelial growth factor (VEGF) and metalloproteinase (MMP) enzymes are responsible for angiogenesis and edema in retinal tissue. The other active marker proteins of angiogenesis associated DR includes epidermal growth factor (EGFR), transforming growth factor (TGF), platelet activating factor (PAF), Hypoxia inducible factor (HIF), integrin, activins and insulin like growth factor. In addition, the neuroinflammation is one of the pathological interventions during DR. Reviewing the factors associated with pathogenesis of retinal damage is important therapeutic marker for research of novel drugs by keeping focus on patient vision. This review points out the novel anti-angiogenic drugs useful for the treatment of DR.
Citation: Shivashankar M (2023) Molecular Mechanism of Diabetic Retinopathyand Its Pharmacotherapy: A Brief Review. Int J Res Dev Pharm L Sci, 9: 149.
Copyright: © 2023 Shivashankar M. This is an open-access article distributedunder the terms of the Creative Commons Attribution License, which permitsunrestricted use, distribution, and reproduction in any medium, provided theoriginal author and source are credited.
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