Review Article
Molecular Mechanism Underlying PD Pathogenesis-A Possible Role for Sphingosine Kinases and Sphingosine-1-Phosphate
Meenalochani S, Dheen ST and Tay SSW*
Department of Anatomy, National University Health system, National University of Singapore, Singapore
- Corresponding Author:
- Tay SSW
Department of Anatomy, Yong Loo Lin School of Medicine
National University of Singapore, Singapore
Tel: (65) 6516 3210
Fax: +65-6778-7643
Email: anttaysw@nus.edu.sg
Received date: October 28, 2015; Accepted date: November 26, 2015; Published date: December 03, 2015
Citation: Meenalochani S, Dheen ST, Tay SSW (2015) Molecular Mechanism Underlying PD Pathogenesis-A Possible Role for Sphingosine Kinases and Sphingosine-1-Phosphate. J Alzheimers Dis Parkinsonism 5:199. doi:10.4172/2161-0460.1000199
Copyright: © 2015 Meenalochani S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Parkinson’s disease is a neurodegenerative disorder that results in the degeneration of dopaminergic neurons in the substantia nigra (SNc) of the midbrain. Understanding the molecular mechanisms underlying the cause of Parkinson’s disease (PD) has attracted the attention of many researchers in the last few decades. In spite of the recent technical advances in the field of neuroscience, the complete pathophysiology of PD is not fully understood. Dysregulated sphingolipid metabolism has been shown to underlie the pathophysiology of many neurodegenerative disorders. However, the role of these sphingolipids in the pathophysiology of PD is still not known. This paper focuses on the, metabolic pathways that are involved in PD pathogenesis with emphasis on sphingolipids and the possible role played by them in the pathogenesis of PD.
