Review Article
Neurophysiology of Nicotine Addiction
John A. Dani*, Daniel Jenson, John I. Broussard and Mariella De BiasiDepartment of Neuroscience, Center on Addiction, Learning, Memory, Baylor College of Medicine, Houston, Texas 77030-3498, USA
- *Corresponding Author:
- Dr. Dr. John A. Dani
Department of Neuroscience
Center on Addiction, Learning, Memory
Baylor College of Medicine
Houston, Texas 77030-3498, USA
Tel: (713)-798-3710
Fax: (713)-798-3946
E-mail: jdani@bcm.edu
Received January 19, 2011; Accepted April 14, 2011; Published April 20, 2011
Citation: Dani JA, Jenson D, Broussard JI, Biasi MD (2011) Neurophysiology of Nicotine Addiction. J Addict Res Ther S1:001. doi:10.4172/2155-6105.S1-001
Copyright: © 2011 Dani JA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Abstract
Tobacco use is a major health problem, and nicotine is the main addictive component. Nicotine binds to nicotinic acetylcholine receptors (nAChR) to produce its initial effects. The nAChRs subtypes are composed of five subunits that can form in numerous combinations with varied functional and pharmacological characteristics. Diverse psychopharmacological effects contribute to the overall process of nicotine addiction, but two general neural systems are emerging as critical for the initiation and maintenance of tobacco use. Mesocorticolimbic circuitry that includes the dopaminergic pathway originating in the ventral tegmental area and projecting to the nucleus accumbens is recognized as vital for reinforcing behaviors during the initiation of nicotine addiction. In this neural system β2, a4, and a6 are the most important nAChR subunits underlying the rewarding aspects of nicotine and nicotine self-administration. On the other hand, the epithalamic habenular complex and the interpeduncular nucleus, which are connected via the fasciculus retroflexus, are critical contributors regulating nicotine dosing and withdrawal symptoms. In this case, the a5 and β4 nAChR subunits have critical roles in combination with other subunits. In both of these neural systems, particular nAChR subtypes have roles that contribute to the overall nicotine addiction process
