Outcomes of Gastric Bypass Surgery on Drug Pharmacokinetics
*Corresponding Author:Received Date: Dec 01, 2023 / Accepted Date: Dec 30, 2023 / Published Date: Dec 30, 2023
Copyright: © 2024 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Gastric bypass surgery, a common bariatric procedure for weight loss, is associated with significant alterations
in gastrointestinal anatomy and physiology. These changes can have profound effects on the pharmacokinetics of
various medications, necessitating careful consideration in clinical management. The surgery-induced modifications
to the digestive tract, including the creation of a small stomach pouch and rerouting of the small intestine, result
in altered drug absorption kinetics. Medications absorbed in the stomach or upper small intestine may experience
changes in bioavailability, leading to potential therapeutic implications. The variable gastric emptying time post-
surgery further complicates drug absorption dynamics, influencing the timing and extent of drug entry into the
systemic circulation. This comprehensive review synthesizes current knowledge regarding the impact of gastric
bypass surgery on drug pharmacokinetics.
