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Abstract

Pregnancy presents a unique challenge in drug therapy due to the dynamic physiological changes that impact drug metabolism and response in both the mother and fetus. Pharmacogenomics offers a promising approach to optimize medication management during pregnancy by elucidating genetic factors influencing drug metabolism, efficacy, and safety. This abstract explores the role of pharmacogenomics in tailoring drug therapy for maternal and fetal health. Genetic variations in drug-metabolizing enzymes, transporters, and targets can significantly affect drug pharmacokinetics and pharmacodynamics, thus influencing individual responses to medications during pregnancy. By integrating pharmacogenomic insights into prenatal care, clinicians can make informed decisions regarding drug selection, dosing, and monitoring to minimize the risk of adverse reactions while maximizing therapeutic efficacy for both the mother and fetus. Despite challenges such as the need for standardized testing protocols and interpretation of genetic data, pharmacogenomics holds the promise of personalized medicine approaches in pregnancy, paving the way for improved maternal and fetal outcomes. Embracing pharmacogenomic principles in prenatal care represents a crucial step towards enhancing medication safety and effectiveness in pregnancy, ultimately benefiting maternal and fetal health.