Preventing Carcinogenesis with Compounds that Inhibit Cytochrome P450 1A1 and 1B1
Received Date: Mar 12, 2018 / Accepted Date: Mar 21, 2018 / Published Date: Mar 29, 2018
Abstract
Cytochrome P450 1A1 and 1B1 convert polycyclic aromatic hydrocarbons to carcinogenic compounds in extrahepatic tissues. In 1997, resveratrol, a naturally occurring stilbene found in grapes and red wine, was found to inhibit the growth of tumors and that one potential mechanism was by inhibiting cytochrome P450 1A1 and 1B1. This prompted further research on various stilbene derivatives as chemopreventive agents. It has recently been discovered that aryl morpholino triazenes represent a new class of cytochrome P450 1A1 and 1B1 inhibitors opening up the field to explore another type of potential chemopreventive agent.
Keywords: Triazenes; Chemopreventive; Stilbenes; Cytochrome P450 1A1; Cytochrome P450 1B1
Citation: Iimoto D (2018) Preventing Carcinogenesis with Compounds that Inhibit Cytochrome P450 1A1 and 1B1. Biochem Physiol 7: 230. Doi: 10.4172/2168-9652.1000230
Copyright: ©2018 Iimoto D. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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