黑料网

Abstract

The proteomic analysis of vitreous fluids provides valuable insights into the molecular differences between individuals with type 2 diabetes and non-diabetic controls. This study aimed to elucidate distinct protein profiles that may underlie diabetic retinopathy, a common complication of diabetes affecting the retina. Vitreous samples were collected from type 2 diabetic patients and non-diabetic individuals undergoing vitrectomy for other ocular conditions. Using mass spectrometry-based proteomics, we identified and compared protein expression patterns between the two groups. Our findings reveal significant alterations in the proteome of vitreous fluids from diabetic patients compared to non-diabetic controls. Several proteins involved in inflammation, angiogenesis, oxidative stress response, and extracellular matrix remodeling were found to be dysregulated in diabetic vitreous fluids. Notably, proteins associated with the pathogenesis of diabetic retinopathy, such as vascular endothelial growth factor (VEGF) and various cytokines, exhibited differential expression levels. The differential protein expression profiles observed in diabetic vitreous fluids highlight potential biomarkers and therapeutic targets for diabetic retinopathy. Understanding these molecular changes may lead to the development of targeted interventions aimed at preventing or slowing the progression of diabetic eye complications. Further validation of identified biomarkers and exploration of their functional roles are warranted to advance our understanding and management of diabetic retinopathy. This proteomic analysis underscores the utility of vitreous fluid analysis in elucidating disease mechanisms and identifying diagnostic and therapeutic avenues for diabetic retinopathy.