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Abstract

Anticoagulants play a crucial role in the management of thromboembolic disorders, with novel anticoagulants (NOACs) providing significant advancements over traditional therapies. This article reviews real-world evidence on the safety and efficacy profiles of NOACs across diverse populations, including different age groups, ethnicities, and co-morbid conditions. By analyzing data from large-scale observational studies and registries, we evaluate the effectiveness of NOACs in preventing stroke and systemic embolism in atrial fibrillation, venous thromboembolism, and other indications. Additionally, we explore the variations in safety outcomes, such as bleeding risks and adverse events, highlighting how real-world experiences align or differ from clinical trial findings. This review aims to provide a comprehensive understanding of NOACs' performance in varied clinical settings, informing treatment decisions and future research directions.