Risks and Triggers of Psychosis in Parkinson Disease
Received Date: Dec 25, 2017 / Accepted Date: Jan 03, 2018 / Published Date: Jan 10, 2018
Abstract
Psychosis is a common non-motor complication in Parkinson disease, and affects the quality of life of patients and their care-givers. This psychosis is caused by intrinsic (pathological and genetic) and extrinsic factors. Pathological factors include the severity of Lewy body pathology, degeneration of cholinergic neurons and overstimulation of serotonin receptors. Genetic factors include apolipoprotein ε4, cholecystokinin genotyping, and glucocerebrosidase mutations. Extrinsic factors that trigger psychosis include systemic inflammation and medication of risky drugs. To prevent such psychosis, it is important to examine systemic infection, cease high-risk drugs, and then consider prescription of anti-psychotic drugs. This review is to discuss pathogenesis and therapeutic strategy of psychosis in Parkinson disease.
Keywords: C-reactive protein; Cognition; Psychosis; Hallucination; Delusion; Lewy body
Citation: Sawada H, Oeda T, Umemura A, Satoshi T, Kohsaka M, et al. (2018) Risks and Triggers of Psychosis in Parkinson Disease. J Alzheimers Dis Parkinsonism 8: 413. Doi: 10.4172/2161-0460.1000413
Copyright: ©2018 Sawada H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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