Role of Ferroptosis in Brain Disease
Abstract
Ferroptosis, a recently identified form of regulated cell death characterized by iron-dependent lipid peroxidation, has emerged as a critical player in the pathophysiology of various brain diseases. In neurodegenerative diseases, such as Alzheimer's, Parkinson's, and Huntington's, dysregulation of iron homeostasis and increased oxidative stress contribute to neuronal damage and cell death. Ferroptosis-related markers have been identified in post-mortem brains of individuals with these conditions, suggesting a potential involvement of ferroptosis in the progression
of these diseases. Additionally, ischemic stroke and Traumatic Brain Injury (TBI) are associated with a surge in
oxidative stress, leading to lipid peroxidation and neuronal death. Ferroptosis has been implicated as a mediator of
secondary brain injury in these cases, presenting a novel target for therapeutic intervention. This abstract provides
a comprehensive overview of the action of ferroptosis in brain disorders, highlighting its molecular mechanisms, key
regulators, and potential therapeutic implications.
