Role of Mitochondrial Zinc in Progression of Prostate Cancer: A Diagnostic Biomarker for Prostate Cancer
Received Date: Nov 09, 2020 / Accepted Date: Nov 24, 2020 / Published Date: Nov 30, 2020
Abstract
Prostate gland is a complex organ found in men, having different components which are named as peripheral, central zone and a periurethral region. Biomarkers development for screening and detection of prostate cancer proved crucial in its easy and early management. Mitochondrial Zinc plays a crucial role in progression of prostate cancer. Peripheral zone of prostate gland has uncommon feature of zinc accumulation which result in collection and secretion of high level of citrate along with components of semen. High amount of zinc inhibit the action of m-aconitase which in turn inhibits citrate oxidation. This review describes the metabolic zinc relationships found in normal and malignant prostate. In this review paper, we will also review the current knowledge on prostate cancer biomarkers such as PSA, PCA3, TMPRSS2-ERG, α-Methylacyl–coenzyme a racemase. Validation of existing biomarkers is essential and future research should focus in validation of existing biomarkers along with discovery of new biomarkers
Keywords: Prostate cancer; Biomarkers; Metabolism; Zinc
Citation: Rana R, Kant R, Ganguly NK, et al. (2020) Role of Mitochondrial Zinc in Progression of Prostate Cancer: A Diagnostic Biomarker for Prostate Cancer. J Oncol Res Treat 5: 152. Doi: 10.4172/aot.1000153
Copyright: © 2020 Rana R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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