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ISSN: 2167-0846

Journal of Pain & Relief
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  • J Pain Relief ,
  • DOI: 10.4172/2167-0846.13.S3.001

Silent Synapses in Cortical Excitation: Chronic Pain and Emotional Disorders

Qi Yu Chen1 and Min Zhuo2,3*
1CAS Key Laboratory of Brain Connectome and Manipulation, Interdisciplinary Center for Brain Information, Chinese Academy of Sciences Shenzhen Institute of Advanced Technology, Shenzhen, China
2Department of Neurology, Zhuomin International Institute for Brain Research, Qingdao, China
3Department of Physiology, University of Toronto, Toronto, Canada
*Corresponding Author : Dr. Min Zhuo, Department of Physiology, University of Toronto, Toronto, Canada, Email: min.zhuo@utoronto.ca

Received Date: Jan 02, 2024 / Published Date: Feb 01, 2024

Abstract

A recent review summarized some recent work of silent synapses in pain-related cortex, and proposed that it may exist as a key synaptic mechanism for cortical circuit LTP and its spreading in chronic pain. We highlighted those key findings of silent synapses and further extended the theories to explaining the mechanism of how corticalrelated connections mediated the chronic pain and its related emotional disorders.

Keywords:   Chronic pain, Anterior cingulate cortex, Silent synapses,  AMPA receptors, NMDA receptors

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Citation: Chen QY, Zhuo M (2024) Silent Synapses in Cortical xcitation: Chronic Pain and motional Disorders. J Pain Relief Open S3: 001. Doi: 10.4172/2167-0846.13.S3.001

Copyright: © 2024 Chen QY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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