Review Article
Synaptic Function and Dysfunction in Alzheimer's Disease
Origlia N1* and Domenici L1,2*1Neuroscience Institute of the National Council of Research (CNR), 56124 Pisa, Italy
2Department of Applied Clinical Sciences and Biotechnology (DISCAB), University of L’Aquila, 67100 L’Aquila, Italy
- Corresponding Authors:
- Luciano Domenici
Department of Applied Clinical Sciences and Biotechnology (DISCAB)
University of L’Aquila, 67100 L’Aquila, Italy
Tel: +390503153193
E-mail: domenici@in.cnr.it - Nicola Origlia
Neuroscience Institute of the National Council of Research (CNR)
56124 Pisa, Italy
Tel: +390503153193
E-mail: origlia@in.cnr.it
Received date: May 20, 2017; Accepted date: June 20, 2017; Published date: June 27, 2017
Citation: Origlia N, Domenici L (2017) Synaptic Function and Dysfunction in Alzheimer’s Disease. J Alzheimers Dis Parkinsonism 7:341. doi:10.4172/2161- 0460.1000341
Copyright: © 2017 Origlia N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease, primarily affecting the elderly. Pathophysiological mechanisms have been elucidated in the past decades. First of all, AD is progressive leading to cognitive deficits till dementia. Pathologically, AD features synaptic dysfunction with changes of neuronal circuitry, progressive accumulation of protein aggregates such as the beta amyloid and tau. Herein we critically review neurobiological processes and factors involved in AD, in light of recent results on synaptic dysfunction and impairment of neuronal activity.
