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Targeting Prion-like Cis Phosphorylated Tau Pathology in Neurodegenerative Diseases

Onder Albayram^1,2#, Peter Angeli^1,2#, Elizabeth Bernstein^1,2, Sean Baxley^1,2, Ziang Gao^1,2, Kun Ping Lu^1,2,3,4 and Xiao Zhen Zhou^1,2*

¹Division of Translational Therapeutics, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, CLS 0408, Boston, MA 02215, , USA

²Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, CLS 0408, Boston, MA 02215, , USA

³Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, , USA

⁴Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine Fujian Medical University, Fuzhou, Fujian, , China

^#Contributed equally to this work