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Abstract

Chronic Kidney Disease (CKD) and atherosclerosis share a complex, bidirectional relationship that exacerbates both conditions. CKD can significantly worsen atherosclerosis through mechanisms such as chronic inflammation and vascular calcification, which accelerate arterial damage and plaque formation. Conversely, atherosclerosis can complicate CKD by impairing renal perfusion and function. This interplay necessitates a comprehensive approach to managing cardiovascular risk factors in CKD patients. Effective strategies include controlling blood pressure, managing cholesterol levels, and addressing other cardiovascular risks to mitigate the progression of both CKD and atherosclerosis. This review highlights the importance of an integrated management plan to prevent and manage the progression of these interrelated conditions, emphasizing the need for early intervention and ongoing monitoring.