The Effect of Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors on Urinary Tract Infections
Received Date: Jun 29, 2022 / Published Date: Jul 29, 2022
Abstract
Objective: Sodium-glucose cotransporter-2 inhibitors are used to treat diabetes by increasing glucose excretion into urine, leading to glycosuria. Although glycosuria increases risk of urinary tract infections, there is a lack of strong evidence showing such an increase with sodium-glucose cotransporter-2 inhibitor use.
Methods: Urine samples from Sodium-glucose cotransporter-2 inhibitor-exposed diabetic patients were inoculated with strains of E. coli (UTI89, LRPF007, and W3110), and bacterial growth was measured using changes in OD600.
Results: Change in OD600 was significantly higher for the nonpathogenic W3110 strain in diabetic patients with history of recurrent urinary tract infections compared to those with no or sporadic history of urinary tract infections. Conclusion: The two uropathogenic strains grew well in urine from all patient groups, possibly due to having defenses against the inhibitory factors in urine that prevent bacterial growth. Sodium-glucose cotransporter-2 inhibitor-exposed patients do not have more Urinary tract infections than the general population because they may have sufficient levels of inhibitory factors to prevent infection.
Citation: Fan EM, Seyan ZJ, Hogins JB, Christie AL, Abreu M, et al. (2022) The Effect of Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors on Urinary Tract Infections. J Clin Diabetes 6: 147. Doi: 10.4172/jcds.1000147
Copyright: © 2022 Fan EM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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