The Predictive Role of Intra-Tumoral CD8+T Cells with Stem Cell-Like Properties in Response to and Efficacy of Anti-PD-1/L1 Treatment
Received Date: Jan 19, 2022 / Published Date: Feb 15, 2022
Abstract
A Checkpoint Inhibitor-Based Immunotherapy (ICIs) has demonstrated outstanding efficacy in many solid tumors. However, some treated patients with positive expression of PD-L1 do not respond, and even develop hyper progression, and some patients with negative expression of PD-L1 can also benefit from immunotherapy combined with chemotherapy. There is growing need to identify biomarkers that will improve the selection of patients who will best respond to therapy. Intra-tumoral effective T cells are critical for anti-tumor effect, and some subpopulation of it have been verified as potential biomarkers for ICIs. In our previous study, a subset of intra-tumoral CD8+ T cells with stem-like properties has been identified as sensitive biomarker for predicting the response to and efficacy of PD-1/L1 blockade treatment with or without chemotherapy. In the current comment, the role and challenges of this cell subpopulation in anti-PD-1/L1 immunotherapy will be discussed.
Keywords: Non-small cell lung cancer; PD-1/L1 immunotherapy; CD8+ T cells; Biomarker
Citation: Fang X, Tang R, Chen R, Luo Z, Xu X, et al. (2022) The Predictive Role of Intra-Tumoral CD8+T Cells with Stem Cell-Like Properties in Response to and Efficacy of Anti-PD-1/L1 Treatment. J Oncol Res Treat S1: 002. Doi: 10.4172/aot.7.s1.1000002
Copyright: © 2022 Fang X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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