Total or Sub-Total Correction of a Marked and Long-standing Cardiac Dysrhythmia after Sofosbuvir/Ledispavir Treatment
Received Date: Sep 15, 2017 / Accepted Date: Sep 25, 2017 / Published Date: Sep 29, 2017
Abstract
Cardiac dysrhythmias (atrial and/or ventricular fibrillation) represent a major medical problem, with possibly life-threatening complications, necessitating costly, life-long treatments or complicated procedures. We report here a case of a sustained correction of a severe and long-standing atrial dysrhythmia (hyperexcitability) and at a lesser degree, a ventricular hyperexcitability, occurring after treatment with a combination of sofosbuvir plus ledispavir administered to treat a chronic Hepatitis C virus infection (HCV). The correction appeared within the first days of anti-HCV treatment and was totally maintained 3 months after drug cessation and still noticeable 3 more months. The mechanism of such an antiarrhythmic action has still to be elucidated. If confirmed, the potential antiarrhythmic effect of sofosbuvir combined with another antiviral drug, could represent a real advance in atrial and maybe ventricular hyperexcitability treatment.
Keywords: Cardiac arrhythmia; Atrial fibrillation; Extrasystoles; Sofosbuvir; Ledispavir; HCV
Citation: Slama G, Slama L, Blacher J, Sebbah J, Bèze YE, et al. (2017) Total or Sub-Total Correction of a Marked and Long-standing Cardiac Dysrhythmia after Sofosbuvir/Ledispavir Treatment. J Chem Biol Ther 2: 114. Doi: 10.4172/2572-0406.1000114
Copyright: © 2017 Slama G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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