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Abstract

Pain remains a significant clinical challenge, affecting millions globally and imposing a substantial burden on healthcare systems. Translational research in pain therapy aims to bridge the gap between basic scientific discoveries and their application in clinical settings. This article reviews the current state of translational research in pain therapy, highlighting key challenges, including the complexity of pain mechanisms, high failure rates in clinical trials, and the opioid crisis. Recent advancements, such as targeted ion channel therapies, gene therapy, neurostimulation techniques, and non-pharmacological approaches, are explored. The article also discusses future directions, including precision medicine, advanced drug delivery systems, artificial intelligence, and combination therapies. Overcoming translational hurdles requires a multidisciplinary approach, innovative research, and improved animal models to develop effective, personalized pain management strategies. This comprehensive overview underscores the importance of translational research in advancing pain therapy and improving patient outcomes.