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Abstract

Allergic asthma is a prevalent chronic inflammatory disorder characterized by airway hyperresponsiveness and inflammation. Macrophages, key players in the immune response, exhibit remarkable plasticity and can adopt distinct functional phenotypes known as polarization. In allergic asthma, the balance between pro-inflammatory M1 and anti-inflammatory M2 macrophages profoundly influences disease progression. This abstract provides a concise overview of the role of macrophage polarization in allergic asthma pathogenesis. It highlights the contributions of M1 and M2 macrophages to airway inflammation, tissue damage, and repair. Understanding the dynamics of macrophage polarization offers insights into disease mechanisms and potential therapeutic targets. By targeting macrophage polarization, novel therapeutic strategies may emerge, offering hope for more effective management of allergic asthma.