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Abstract

A possible alternate approach for determining systemic toxicity is likely to be read-across based on structural and biological similarities. Stacking case studies and gleaning important points from them would be a practical technique for quantitative chemical risk assessment. Thus, by contrasting the toxicological consequences based on bad outcome pathways and exposure levels of various structurally comparable compounds for a target organ, we produced a readacross case study. We focused on the hepatotoxicity of triclosan, diclosan, and 1-chloro-3-(4-chlorophenoxy)benzene, which share structural similarities with triclosan. According to the findings of in vitro toxicogenomics, both triclosan and diclosan were frequently found to cause abnormalities in cholesterol production. Both triclosan and diclosan treatment led to equal reductions in hepatocellular cholesterol levels. Furthermore, the liver's exposure to diclosan and triclosan was comparable. These findings demonstrate that the toxicological effects and degree of hepatotoxicity of triclosan and diclosan are comparable. Our prediction results about the toxicological effect and its severity are credible in light of the available repeated dose toxicity data. The current study thus illustrated the applicability of read-across comparison of toxicological effects and exposure levels for quantitative chemical risk assessment.