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Abstract

Wernicke-Korsakoff syndrome (WKS) is a neurological disorder stemming from a deficiency in vitamin B-1; also known as thiamine. This syndrome comprises two distinct conditions; Wernicke’s encephalopathy and Korsakoff’s psychosis; which can manifest simultaneously or independently. Wernicke’s encephalopathy typically precedes Korsakoff’s psychosis; showcasing symptoms such as confusion; ataxia; and oculomotor disturbances. The progression to Korsakoff’s psychosis involves severe memory impairment; confabulation; and behavioral changes. The etiology of WKS is often linked to chronic alcoholism; malnutrition; and other conditions leading to thiamine deficiency. Early recognition and prompt thiamine supplementation are crucial for improving outcomes in individuals affected by WKS. This abstract highlights the clinical features; diagnostic criteria; pathophysiology; and management strategies pertinent to Wernicke-Korsakoff syndrome.