Why is Alcohol-Induced Atrial Arrhythmias and Sudden Cardiac Death Difficult to Prevent and Treat: Potential Roles of Unrecognized Ionized Hypomagnesemia and Release of Ceramides and Platelet-Activating Factor

Burton M Altura; Nilank C Shah; Gatha J Shah; Bella T Altura

Why is Alcohol-Induced Atrial Arrhythmias and Sudden Cardiac Death Difficult to Prevent and Treat: Potential Roles of Unrecognized Ionized Hypomagnesemia and Release of Ceramides and Platelet-Activating Factor

Burton M Altura^1,^2,^3,^4,⁵^*, Nilank C Shah^1,⁵, Gatha J Shah¹ and Bella T Altura^1,^2,^3,^4,⁵: ¹Department of Physiology And Pharmacology, State University of New York, Downstate Medical Center, USA; ²Department of Medicine, State University of New York, Downstate Medical Center, USA; ³Center for Cardiovascular and Muscle Research, State University of New York, Downstate Medical Center, USA; ⁴School of Graduate Studies in Molecular and Cellular Science, State University of New York, Downstate Medical Center, USA; ⁵Bio-Defense Systems, Inc, , Rockville Centre State, New York, USA

^*Corresponding Author : Burton M Altura, Department of Physiology And Pharmacology, School of Graduate Studies in Molecular and Cellular Science, SUNY Downstate Medical Center, Brooklyn, New York, USA, Tel: 718-270-2194, Email: baltura@downstate.edu

Received Date: Jul 25, 2016 / Accepted Date: Aug 26, 2016 / Published Date: Oct 02, 2016

Abstract

Heart failure is the leading worldwide cause of morbidity, myocardial infarctions and mortality whose causes impose staggering costs and often lengthy hospitalizations. The specific reasons (or mechanisms) to explain or predict atrial arrhythmias in alcoholics or” binge- drinkers” are not known. The authors present evidence for a novel, new hypothesis whereby low tissue and serum levels of ionized magnesium(Mg2+) coupled to release of ceramides and platelet-activating factor (PAF) act to increase risk for cardiac atrial arrhythmias in people who imbibe too much alcoholic spirits over a short-period of time(i.e., binge-drinkers) or are alcohol abusers. The authors discuss several mechanisms whereby low Mg2+ and the generation of PAF and ceramides produce a high probability for atrial arrhythmias in alcoholics. The importance of adequate water-borne and dietary levels of Mg is emphasized

Keywords: Alcohol abuse; Sphingolipids; PAF; Ionized magnesium; Microcirculation

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Citation: Altura BM, NC Shah, Shah GJ, Altura BT (2016) Why is Alcohol- Induced Atrial Arrhythmias and Sudden Cardiac Death Difficult to Prevent and Treat: Potential Roles of Unrecognized Ionized Hypomagnesemia and Release of Ceramides and Platelet-Activating Factor. Cardiovasc Ther 1: 112.

Copyright: © 2016 Altura BM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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