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Pericardial cysts are rare mediastinal abnormalities. We report on a 54-year-old male, who was found to have a large right-sided pericardial cyst incidentally. Multiple imaging modalities including 2D echocardiography, contrast echocardiogram with DEFINITY, transesophageal echocardiography and CT scan were used to delineate the features of the pericardial cyst. Patient was asymptomatic and was managed conservatively.

Pericardial cyst; Echocardiography; Transesophageal echocardiography; Contrast echocardiography

Pericardial cysts are a rare benign anomaly in the mediastinum. They are often found in either cardiophrenic angle. It is postulated that pericardial cysts are derived from failed fusion of one of the mesenchymal lacunae normally forming the pericardial sac [1]. Incidence of pericardial cysts is estimated to be 1:100,000 [2]. Pericardial cysts consist of about 7% of all mediastinal masses [2,3].

Most commonly, they have no associated symptoms and are discovered incidentally during a routine chest X-ray or echocardiography. Episodes of chest pain, shortness of breath, cough or persistent arrhythmia have been described. Other complications, such as congestive heart failure, right ventricular outflow tract obstruction, infection and pulmonary stenosis have been reported. CT scan, MRI and transesophageal echocardiography are the common imaging modalities of choice for diagnosis and follow up.

This is a 54-year-old white male with past medical history of hypertension, who was admitted to a local hospital with chief complaint of diarrhea, vomiting and epigastric pain. He denies chest pain or shortness of breath. He has “fullness” feeling at the epigastric area for several years. In the emergency room, patient underwent CTA of the chest to rule out pulmonary embolism.

CTA of the chest revealed a thin-walled, sharply defined and oval homogenous right mediastinal mass, measuring 5.9 × 4.0 cm², suggestive of a pericardial cyst (Figure 1).

Patient was discharged from the emergency room and was referred to us due to the pericardial cyst. Patient was asymptomatic. Routine transthoracic echocardiogram (2D echo) revealed a 4.1 × 4.4 cm² cystic structure (red arrow) adjacent to the right atrium, consistent with possible pericardial cyst (Figure 2).

DEFINITY is a perflutren lipid microsphere and is injected intravenously to opacify cardiac chambers and to improve the delineation of the endocardial border. Figure 3 shows DEFINITY opacifies the right atrium and the right ventricle. However, the pericardial cyst, which is adjacent to the right atrium, does not fill with the contrast agent. This study suggests that there is no communication between pericardial cyst and the heart.

To further delineate the structure of the pericardial cyst, a transesophageal echocardiogram (TEE) was performed. TEE revealed a large pericardial cyst adjacent to the right atrium which had no direct communication with the pericardial space (Figure 4). Since the patient was asymptomatic from a cardiac point of view, he was offered conservative management.

Pericardial cysts are a rare congenital abnormality that occurs in the middle mediastinum. Pericardial cysts range from 1 to 5 cm in size [4]. They are rarely found in children and are more commonly found in the third or fourth decade of the life [3]. They usually have no communication with the pericardial space. They are unilocular, have smooth walls with an outer layer of endothelial or mesothelial cells. They are usually asymptomatic are often discovered incidentally on chest X-ray. Echocardiography can further delineate the cardiac structures as it can differentiate other possible cardiac abnormalities, such as left ventricular aneurysm, aortic aneurysm, prominent fat pad or a loculated pericardial effusion. 2D echo with contrast agent and TEE may provide incremental value in the diagnosis of pericardial cyst. In this case report, we used multiple imaging modalities, including 2D echo, TEE and CT scan to characterize the pericardial cyst. To the best of our knowledge, this is the first report, using contrast agent (DEFINITY) to further characterize a pericardial cyst.

The management of pericardial cysts depends on the appearance of the cysts and symptoms of the patient. Asymptomatic patients can be managed conservatively with close follow up. Some pericardial cysts may resolve spontaneously, the probable mechanism being the rupture of the cyst. For patients with pericardial cysts who develop symptoms, percutaneous aspiration or surgical excision with either a thoracotomy or video-assisted thoracoscopic surgery should be considered [5-7].