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Quantitative evaluation of liver capability is important not only for observing that function but also for evaluating the liver reserve prior to surgery [1].

Since Indocyanine Green is only removed from distribution by the liver, the Plasma Disappearance Rate has been regarded as an important tool for quantitatively evaluating liver function [2]. However, to our knowledge, there is no established method for the quantitative anatomically based assessment of segmental liver capability (Figure 1).

Figure 1: Real-time MRI imaging of Liver.

It has been established that a quantitative liver function test, such as the ICG clearance test, and the Future Remnant Liver Volume are significant predictors of postoperative liver failure and mortality [1,3].However, because the heterogeneity of the liver function could not be taken into account with volumetry, an accurate assessment of the segmental liver reserve may not be possible [4].

Gadoxetate disodium is a paramagnetic hepatobiliary contrast specialist that has the ability to combine the characteristics of a hepatocellular contrast agent and extracellular agents. The same transportation frameworks (for instance the Natural Anion Shipping Polypeptides, OATPs) are seen as obligated for take-up of gadoxetate disodium and ICG in hepatocytes. As a result, gadoxetate disodiumimproved MR imaging may serve as the foundation for a useful method for quantitatively assessing postoperative liver disappointment, such as ICG clearance, while also allowing for anatomic delineation of hepatic function.

1. Seyama Y, Kokudo N (2009) . Hepatol Res 39: 107-116.

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2. Sakka SG (2007) . Curr Opin Crit Care 13: 207-214.

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3. Suda K, Ohtsuka M, Ambiru S, Kimura F, Shimizu H, et al. (2009) . Am J Surg 197: 752-758.

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4. Yamada A (2012) Quantitative Evaluation of Liver Function within MR Imaging. OMICS J Radiol 1: e109.