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Research Article

Achilles Tendon Rupture and Abnormal Lipid Profile: A Descriptive Clinical Laboratory and Histology Study

¹Orthopaedic and Traumatology Surgery Service, University Hospital of Besançon, Besançon France Intervention, Innovation, Imagery, Engineering in Health, Medical and Pharmacology Section, University of Franche-Comté, Besançon, France

²Department of Anatomy and Cell Pathology, CHU Jean Minjoz, Boulevard Alexandre Fleming Besançon, France

Corresponding Author:

François L
Orthopaedic and Traumatology Surgery Service
University Hospital of Besançon 25000
Besançon France Intervention, Innovation, Imagery
Engineering in Health (EA 4268), Medical and Pharmacology Section
IFR 133, University of Franche-Comté 25000, Besançon, France
Tel: (33) 06 31 98 75 32
E-mail: francois_loisel@yahoo.fr

Received Date: October 20, 2016; Accepted Date: November 05, 2016; Published Date: November 11, 2016

Citation: François L, Kielwasser H, Faivre G, Bernadette K, Laurent O (2016) Achilles Tendon Rupture and Abnormal Lipid Profile: A Descriptive Clinical Laboratory and Histology Study. Clin Res Foot Ankle 4:214. doi:10.4172/2329-910X.1000214

Copyright: © 2016 François L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Introduction: Several human and animal studies have revealed a link between abnormal serum lipid levels and Achilles tendon rupture. However, clinicians have not detected macroscopic amounts of fatty tissue during the repair of ruptured tendons.
Material and Methods: A lipid profile and evaluation of tendon lipomatosis were performed in a group of 65 patients with Achilles tendon rupture recruited over a two-year period at two French hospitals. Cardiovascular and tendon rupture risk factors were inventoried.
Results: Ten patients had a history of hypercholesterolemia, seven of whom were undergoing statin treatment (15%). Two patients had known risk factors for tendon rupture (3%): one was taking inhaled corticosteroids and the other suffered from hyperuricemia. Total cholesterol was normal in 63% of cases; triglycerides were normal in 67% of cases and HDL cholesterol was normal in 54% of cases. If cardiovascular risk factors were taken into account, the portion of high-LDL cholesterol went from 17% to 23%, but this was not significant. Pathology analysis found four cases of tendon lipomatosis among the 36 collected samples (11%).
Discussion: Since this study did not include a control group, we cannot make any conclusions about the lack of relationship between abnormal lipid profile and tendon rupture. The prevalence of hypercholesterolemia in our study population was similar to that of the general population. Although high cholesterol levels have been implicated by some authors, cholesterol accumulation within the tendon is probably not directly responsible for weakening it; however, an increase in atheromatous plaque in tendon blood vessels may lead to hypoxia.

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