Anti-Hu Antibody- and Anti-Zic4 Antibody-Positive Paraneoplastic Neurological Syndrome Presenting with Cerebellar Degeneration and Cranial Neuropathy: A Case Report
Received Date: Oct 06, 2022 / Accepted Date: Oct 20, 2022 / Published Date: Oct 27, 2021
Abstract
We present an illustrative case of a 62-year-old woman who developed progressive worsening of neurological symptoms with the simultaneous involvement of both peripheral and central nervous system. Our patient presented high titers of Anti-Hu and anti-Zic4 antibodies in her serum. We review the literature and found that multiple cranial palsies and concurrent cerebellar degeneration are uncommon in anti-Hu paraneoplastic syndromes. The patient was treated with intravenous immunoglobulin and methylprednisolone without significant improvement of symptoms.
Keywords: Cranial neuropathy, Cerebellar degeneration, Neurologic immune related adverse events, anti-Hu antibody, Paraneoplastic syndrome, case report
Citation: Kourtesis I, Orianou , Asteris Y, Georgatos G, Malteou M (2021) Anti-Hu Antibody- and Anti-Zic4 Antibody-Positive Paraneoplastic Neurological Syndrome Presenting with Cerebellar Degeneration and Cranial Neuropathy: A Case Report. J Clin Exp Neuroimmunol 6:134.
Copyright: © 2021 Kourtesis I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Share This Article
Recommended Journals
黑料网 Journals
Article Usage
- Total views: 2849
- [From(publication date): 0-2021 - Nov 22, 2024]
- Breakdown by view type
- HTML page views: 2099
- PDF downloads: 750
