Antiviral Activity of the Hemolymph of Podalia sp and M. Albicolis (Lepidoptera: Megalopigydae)
Received Date: May 31, 2022 / Published Date: Jul 01, 2022
Abstract
Potent antiviral activity against measles, influenza, picornavirus and herpès simplex viruses was observed in the hemolymph of Podalia sp and M. Albicolis (Lepidoptera: Megalopigydae). The antiviral proteins responsible for this activity were isolated by gel filtration chromatography using à gel filtration column system (Superdex 75) and further fractionated using a Resource-Q ion exchange column system. Experiments with the semi-purified protein led to a 128-fold reduction in picornavirus production, 64-fold reduction in measles virus production and a 32-fold reduction in influenza virus replication. qPCR showed a significantly lower level of herpes virus transcription. In addition no citotoxicity and genotoxicity effect was observed for Vero cells, suggesting a very interesting potential antiviral activity.
Keywords: Antiviral activity, Lepidoptera: Megalopigydae, Measles, Influenza, Picornavirus, Herpès simplex virus
Citation: Carvalho ND, Curti SP, Oliveira MI, Rofatto HK, Figueiredo CA, et al. (2022) Antiviral Activity of the Hemolymph of Podalia Sp and M. Albicolis (Lepidoptera: Megalopigydae). J Infect Dis Ther S4:005.
Copyright: © 2022 Carvalho ND, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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