CIDP and CASPR1: A Rare Form of CIDP with Severe Neuropathic Pain
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Copyright: © 2019 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most common inflammatory
neuropathy. Recently, autoantibodies against the Para nodal proteins are related to a kind of CIDP with a specific
clinical and manifestations. The Contactin associated protein-1 (CASPR1) is a cell-adhesion protein tightly
associated with Contactin in the Para nodal region and was identified as a possible antigen in inflammatory
neuropathies. Patients with CIDP who presents autoantibodies against CASPR1 have a distinct disease course.
Therefore, this study proposes that patients with CIDP should be tested to CASPR1.
