Dorsal Root Ganglia Nociceptors Provide a Protective Barrier, Invasion, and Spread of STM (Salmonella Enterica Serovar Typhimurium) from the Gastrointestinal Tract
Received Date: May 02, 2023 / Published Date: May 30, 2023
Abstract
Gut-innervating nociceptor sensory neurons reply to noxious stimuli with the aid of initiating protecting responses which includes ache and inflammation; however, their position in enteric infections is unclear. Here, we locate that nociceptor neurons seriously mediate host protection in opposition to the bacterial pathogen Salmonella enterica serovar Typhimurium (STm). Dorsal root ganglia nociceptors shield towards STm colonization, invasion, and dissemination from the gut. Nociceptors modify the density of microfold (M) cell in ileum Peyer’s patch (PP) follicleassociated epithelia (FAE) to restrict entry factors for STm invasion. Downstream of M cells, nociceptors preserve tiers of segmentous filamentous microorganism (SFB), a intestine microbe living on ileum villi and PP FAE that mediates resistance to STm infection.
Citation: Shwetank F (2023) Dorsal Root Ganglia Nociceptors Provide a Protective Barrier, Invasion, and Spread of STM (Salmonella Enterica Serovar Typhimurium) from the Gastrointestinal Tract. J Clin Exp Neuroimmunol, 8: 187. Doi: 10.4172/jceni.1000187
Copyright: © 2023 Shwetank F. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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