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Efficacy and Safety of AKT Inhibitors in HR+/HER2- Breast Cancer or Metastatic TNBC: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Wuzhi Zhong¹, Tao Yan¹, Lehui Li¹, Xinguang Zhang¹, Ru Zhang¹, Dijia Li¹, Lijie Ma¹, Chunfa Zhang¹, Ya Wang¹, Xiaodong Cao¹, Nan Zhang¹ and Ziying Zhang^1,2*

¹Department of Medical Oncology, Basic Medicine College, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China

²Medical Experiment Center, Inner Mongolia Medical University, Hohhot, 010110, China

Received Date: May 03, 2024 / Published Date: Jun 05, 2024

Citation: Zhong W, Yan T, Li L, Zhang X, Zhang R, et al. (2024) Efficacy and Safety of AKT Inhibitors in HR+/HER2- Breast Cancer or Metastatic TNBC: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Infect Dis Ther S7:003.DOI: 10.4173/2332-0877.24.S7.003

Copyright: © 2024 Zhong W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Background: This study aims to investigate the impact of AKT inhibitors (Capivasertib and Ipatasertib) on the efficacy and safety of patients with HR+/HER2- breast cancer or metastatic TNBC.

Methods: A comprehensive search for relevant Randomized Clinical Trials (RCTs) of AKT inhibitors were conducted through PubMed, Embase, and Cochrane Library. The meta-analysis included five studies with a total of 1304 patients. Outcome indicators such as Progression-Free Survival (PFS), Adverse Events (AEs), Overall Survival (OS), Duration of Response (DOR), Objective Response Rate (ORR), and Clinical Benefit Rate (CBR) were analyzed using Review Manager 5.4.1.

Results: Patients treated with AKT inhibitors showed a significant improvement in PFS compared to those without (MD=2.39; 95% CI: 1.06, 3.73; p=0.0005; I2=55%). However, the incidence of some dangerous AEs increased, including infection (OR=1.72; 95% CI: 1.09, 2.72; p=0.02; I2=0%) and hyperglycemia (OR=3.07; 95% CI: 1.36, 6.93; p=0.007; I2=63%).

Conclusion: AKT inhibitors significantly prolonged the survival of patients with metastatic TNBC and HR+/HER2- breast cancer. Nevertheless, the occurrence of AEs, such as infection and hyperglycemia, during AKT inhibitor treatment suggests the need for careful and rational drug usage based on specific patient conditions.

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