Efficacy of Ceftolozane/Tazobactam in Infections with Multidrug-Resistant Gram-Negative Bacteria: A Preliminary Clinical Experience in a Highly Endemic Hospital
Received Date: Jul 25, 2023 / Published Date: Aug 25, 2023
Abstract
Introduction: Ceftolozane/Tazobactam is a new cephalosporin/beta-lactams inhibitor combination proven to be a drug with efficacy against urinary tract infections, abdominal infections and nosocomial ventilator-associated pneumonia, supported by multi-resistant Gram-negative bacteria.
Methods: This retrospective study considerated a cohort of 85 patients (≥ 18 years ), with a Gram-negative infection diagnosed between October 2017 and December 2020, treated with at least 72 hours of C/T therapy. The aim was to evaluate the efficacy, tolerability and to analyze any factors associated with a negative outcome.
Results: The clinical success achieved in patients treated with ceftolozane/tazobactam in this coorte was 59%. Risk factors independently associated with mortality were neutropenia (p=0.02) and ICU stay (p=0.009). High mortality in ICU is related to complexity of patients with multiple devices and concomitant infections that needed combination of antibiotic therapy.
Conclusion: Ceftolozano/tazobactam represents a therapy of choice in infections by Gram-MDR bacteria, also in that which multiple comorbidity and long hospital stay.
Keywords: Multi drug-resistant bacteria; Ceftolozano-tazobactam; Pseudomonas; ICU
Citation: Brescini L, Mazzanti S, Battistelli L, Morroni G, Pallotta F, et al. (2023) Efficacy of Ceftolozane/ Tazobactam in Infections with Multidrug-Resistant Gram-Negative Bacteria: A Preliminary Clinical Experience in a Highly Endemic Hospital. J Infect Dis Ther 11: 558. Doi: 10.4172/2332-0877.1000558
Copyright: © 2023 Brescini L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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