Research Article
Formulation and Evaluation of Fast Dissolving Tablets of Diclofenac Sodium by Novel Hole Technology
| Renati Damodar1*, Babji Movva1, Mallikarjun PN1, Chaitanya Pasumarthy2, Nishanth Kona3 and Varsha PV4 | ||
| 1Department of Pharmaceutics, Vignan Institute of Pharmaceutical Technology, Visakhapatnam, Andhra Pradesh, India | ||
| 2Mother Teresa College of Pharmacy, Ghatkesar, Hyderabad, India | ||
| 3Department of Pharmaceutics, Sree Siddaganga College Pharmacy, Tumkur, Karnataka, India | ||
| 4Department of Biotechnology, GITAM University, Visakhapatnam, Andhra Pradesh, India | ||
| Corresponding Author : | Renati Damodar Department of Pharmaceutics Vignan Institute of Pharmaceutical Technology Visakhapatnam, Andhra Pradesh, India Tel: +918500932050 E-mail: renatidamodar@gmail.com |
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| Received May 27, 2014; Accepted July 28, 2014; Published July 31, 2014 | ||
| Citation: Damodar R, Movva B, Mallikarjun PN, Pasumarthy C, Kona N, et al. (2014) Formulation and Evaluation of Fast Dissolving Tablets of Diclofenac Sodium by Novel Hole Technology. J Mol Pharm Org Process Res 2:116. doi: 10.4172/2329-9053.1000116 | ||
| Copyright: © 2014 Damodar R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | ||
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Abstract
Research has done to prepare Diclofenac Sodium quick dissolving tablets by Hole technology. Once these quick dissolving tablets contact with gastro enteric fluids, the fluid can enter the hole within the tablet and immediate breaking of the tablet goes to take place. This quick disintegration of tablets is additionally influenced by the formation of latest absolute space. The ready FDTs were subjected to numerous pre and post formulation studies. Its disintegration and dissolution rates were compared with the management formulation (without hole). In-vitro drug release of FDTs (DH6) showed virtually 100.92% of the drug was discharged at sixth minute, whereas the management formulation D12 shows the 99% drug release at 20th minute. Overall, this method is novel and most helpful for formulation into quick dissolving tablets.
